Cranial neuralgias: from physiopathology to pharmacological treatment

Cranial neuralgias are paroxysmal painful disorders of the head characterised by some shared features such as unilaterality of symptoms, transience and recurrence of attacks, superficial and "shock-like" quality of pain and the presence of triggering factors. Although rare, these disorders must be promptly recognised as they harbour a relatively high risk for underlying compressive or inflammatory disease. Nevertheless, misdiagnosis is frequent. Trigeminal and glossopharyngeal neuralgias are sustained in most cases by a neurovascular conflict in the posterior fossa resulting in a hyperexcitability state of the trigeminal circuitry. If the aetiology of trigeminal neuralgia (TN) and other typical neuralgias must be brought back to the peripheral injury, their pathogenesis could involve central allodynic mechanisms, which, in patients with inter-critical pain, also engage the nociceptive neurons at the thalamic-cortical level. Currently available medical treatments for TN and other cranial neuralgias are reviewed

Toward Reverse Engineering of VBA Based Excel Spreadsheet Applications

Modern spreadsheet systems can be used to implement complex spreadsheet applications including data sheets, customized user forms and executable procedures written in a scripting language. These applications are often developed by practitioners that do not follow any software engineering practice and do not produce any design documentation. Thus, spreadsheet applications may be very difficult to be maintained or restructured. In this position paper we present in a nutshell two reverse engineering techniques and a tool that we are currently realizing for the abstraction of conceptual data models and business logic models.Comment: In Proceedings of the 2nd Workshop on Software Engineering Methods in Spreadsheets (http://spreadsheetlab.org/sems15/

Assessing and Improving Industrial Software Processes

Software process is a complex phenomenon that involves a multitude of different artifacts, human actors with different roles, activities to be performed in order to produce a software product. Even though the research community is devoting a great effort in proposing solutions aimed at improving software process, several issues are still open. In this Thesis work I propose different solutions for assessing and improving software processes carried out in real industrial contexts. More in detail, I proposed a solution, based on ALM and MDE, for supporting Gap Analysis processes for assessing if a software process is carried out in accordance with Standards or Evaluation Framework. Then, I focused on a solution based on tool integration for the management of trace links among the artifacts involved in the software process. As another contribution, I proposed a Reverse engineering process and a tool, named EXACT, for supporting the analysis and comprehension of spreadsheet based artifacts involved in software development processes. Finally, I realized a semi-automatic approach, named AutoMative, for supporting the introduction in real Industrial software processes of SPL for managing the variability of the software products to be developed. Case studies conducted in real industrial settings showed the feasibility and the positive impact of the proposed solutions on real industrial software processes

InSAR full-resolution analysis of the 2017–2018 M>6 earthquakes in Mexico

Abstract The present study analyzes the sequence of 4 important earthquakes occurred in Mexico from September 2017 to February 2018, exploiting the large availability of InSAR data and analytical models, with a twofold goal: to privede new solutions for seismogenic sources, completely independent from seismological data, and to discuss methodological aspects related to the non-linear and linear inverse problem. We review and update an earlier study, focused on the concept of resolution, showing the level of detail achievable in the investigation of the slip distribution based on geodetic observations, according to data availability, fault locations and event magnitudes. We further give new insights into the relationship between fault resolution and parameter uncertainty, demonstrating that a realistic assessment is strictly related to a proper fault subdivision. We eventually discourage the use of qualitative approaches, such as the checkerboard test, to evaluate the data resolving power and suggest the adoption of quantitative indicators, like the Dirichlet Spread Function, normalized, easy to calculate and mathematically robust

Multiparametric MRI of the bladder: inter-observer agreement and accuracy with the Vesical Imaging-Reporting and Data System (VI-RADS) at a single reference center

Objectives: To evaluate accuracy and inter-observer variability using Vesical Imaging-Reporting and Data System (VI-RADS) for discrimination between non-muscle invasive bladder cancer (NMIBC) and muscle-invasive bladder cancer (MIBC). Methods: Between September 2017 and July 2018, 78 patients referred for suspected bladder cancer underwent multiparametric MRI of the bladder (mpMRI) prior to transurethral resection of bladder tumor (TURBT). All mpMRI were reviewed by two radiologists, who scored each lesion according to VI-RADS. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were calculated for each VI-RADS cutoff. Receiver operating characteristics curves were used to evaluate the performance of mpMRI. The Ƙ statistics was used to estimate inter-reader agreement. Results: Seventy-five patients were included in the final analysis, 53 with NMIBC and 22 with MIBC. Sensitivity and specificity were 91% and 89% for reader 1 and 82% and 85% for reader 2 respectively when the cutoff VI-RADS > 2 was used to define MIBC. At the same cutoff, PPV and NPV were 77% and 96% for reader 1 and 69% and 92% for reader 2. When the cutoff VI-RADS > 3 was used, sensitivity and specificity were 82% and 94% for reader 1 and 77% and 89% for reader 2. Corresponding PPV and NPV were 86% and 93% for reader 1 and 74% and 91% for reader 2. Area under curve was 0.926 and 0.873 for reader 1 and 2 respectively. Inter-reader agreement was good for the overall score (Ƙ = 0.731). Conclusions: VI-RADS is accurate in differentiating MIBC from NMIBC. Inter-reader agreement is overall good. Key Points: • Traditionally, the local staging of bladder cancer relies on transurethral resection of bladder tumor. • However, transurethral resection of bladder tumor carries a significant risk of understaging a cancer; therefore, more accurate, faster, and non-invasive staging techniques are needed to improve outcomes. • Multiparametric MRI has proved to be the best imaging modality for local staging; therefore, its use in suitable patients has the potential to expedite radical treatment when necessary and non-invasive diagnosis in patients with poor fitness

Nucleation front instability in two-dimensional (2D) nanosheet gadolinium-doped cerium oxide (CGO) formation

Herein we report for the first time the synthesis of ceramic-organic three-dimensional (3D) layered gadolinium-doped cerium oxide (Ce1-XGdXO2-delta,CGO) and its exfoliation into two-dimensional (2D) nano-sheets. We adopt a water-based synthetic route via a homogenous precipitation approach at low temperatures (10-80 degrees C). The reaction conditions are tuned to investigate the effects of thermal energy on the final morphology. A low temperature (40 degrees C) morphological transition from nanoparticles (1D) to two-dimensional (2D) nanosheets is observed and associated with a low thermal energy transition of ca. 2.6 kJ mol(-1). For the 3D-layered material, exfoliation experiments are conducted in water/ethanol solutions. Systems at volume fractions ranging from 0.15 to 0.35 are demonstrated to promote under ultrasonic treatment the delamination into 2D nanosheets

Vibrationally resolved NEXAFS at C and N K-edges of pyridine, 2-fluoropyridine and 2,6-difluoropyridine: A combined experimental and theoretical assessment

In the present work, the near edge X-ray absorption spectroscopy (NEXAFS) spectra at both C and N K-edges of pyridine, 2-fluoropyridine, and 2,6-difluoropyridine have been studied both experimentally and theoretically. From an electronic point of view, both transition potential density functional theory and time-dependent density functional theory approaches lead to reliable results provided that suitable basis sets and density functionals are employed. In this connection, the global hybrid B3LYP functional in conjunction with the EPR-III basis set appears particularly suitable after constant scaling of the band positions. For the N K-edge, vertical energies obtained at these levels and broadened by symmetric Gaussian distributions provide spectra in reasonable agreement with the experiment. Vibronic contributions further modulate the band-shapes leading to a better agreement with the experimental results, but are not strictly necessary for semi-quantitative investigations. On the other hand, vibronic contributions are responsible for strong intensity redistribution in the NEXAFS C K-edge spectra, and their inclusion is thus mandatory for a proper description of experiments. In this connection, the simple vertical gradient model is particularly appealing in view of its sufficient reliability and low computational cost. For more quantitative results, the more refined vertical Hessian approach can be employed, and its effectiveness has been improved thanks to a new least-squares fitting approach

2-Mercaptobenzoxazoles: a class of carbonic anhydrase inhibitors with a novel binding mode to the enzyme active site.

2-Mercaptobenzoxazole represents an interesting lead compound alternative to the classical sulfonamides for the development of selective carbonic anhydrase inhibitors